Publications on the Development of Pharmacokinetics Forensic Analysis
Absorption Rate Analysis (ARA) is a practical investigative tool designed to extract valuable, hidden information about a drug's oral absorption process. The two publications linked below describe the theory and practice of absorption rate analysis up to its present state of development. ARA Biopharmaceutics Review is the organization and interpretation of observations obtained by absorption rate analysis. This provides a 'big picture' view of how an oral drug product interacts with the body, nearly as detailed as if an investigator had witnessed events as they happened. When used in this holistic manner, ARA Biopharmaceutics Review can identify risks to the success of a drug development program, before they appear in the clinic. The most appropriate drug formulation strategy becomes apparent without the trial and error associated with dedicated formulation PK studies. And the method is equally well adapted to investigate the root cause for unexpected or undesirable clinical study results, such as drug-drug interactions and failure to show bioequivalence.